Interaction between major pathways for platelet activation in mouse models of arterial thrombosis

Platelets play a central role in arterial thrombosis, causing life-threatening and disabling diseases like myocardial infarction and ischemic stroke. Despite antiplatelet therapies have been proven efficacious for primary and secondary prevention of cardio- and cerebrovascular diseases, arterial thrombosis remains a major healthy problem. A better understanding of the multiple mechanisms by which platelets can be activated is the basis for the rationale development of new antithrombotic drugs.