Nuclease Immune Mediated Brain and Lupus-like conditions (NIMBL): natural history, pathophysiology, diagnostic and therapeutic modalities with application to other disorders of autoimmunity

In the NIMBL project, clinicians and research scientists have united to share their knowledge and expertise and increase the number of people in the study to benefit all affected families, both now and in the future.

The NIMBL research study aims to gain a greater understanding of:

• the normal progress of these illnesses, including the biochemical changes
• the underlying cause (genetic and biochemical)

This should help to:

• give an earlier, faster and more accurate diagnosis in the future
• suggest and investigate potential new treatments and therapies
• provide insight into other autoimmune conditions (e.g. systemic lupus erythematosus)

The investigation of NIMBL diseases will not only improve the health and well-being of NIMBL patients and their families, it is also expected to lead to better treatments of much more common autoimmune disorders including lupus.